The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery: A meta-analysis for time of intervention

Yuhang Zhang; Ying Qi; Xiaohang Xie; Fengyan Zhang

doi:10.1016/j.aopr.2022.100063

您当前的位置：

首页 >

文章列表页 >

The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery: A meta-analysis for time of intervention

更新时间：2023-11-15

- The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery: A meta-analysis for time of intervention
- AOPR Vol. 2, Issue 3, Pages: 100063(2022)
- 作者机构：
  
  1. ,Zhengzhou,China
  2. ,Zhengzhou,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2022.100063
  CLC：
扫描看全文
Yuhang Zhang, Ying Qi, Xiaohang Xie, et al. The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery: A meta-analysis for time of intervention. [J]. AOPR 2(3):100063(2022)
DOI：

Yuhang Zhang, Ying Qi, Xiaohang Xie, et al. The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery: A meta-analysis for time of intervention. [J]. AOPR 2(3):100063(2022) DOI： 10.1016/j.aopr.2022.100063.

摘要

Purpose,The effect of interventional time for 3% Diquafosol reatment in post-cataract surgery has not been well established. A meta-analysis was performed to evaluate the improvement of ocular surface condition in post-cataract surgery patients who received 3% DQS for various treatment durations.,Methods,Studies were performed based on 5 databases: PubMed, Cochrane Library, Web of Science, Embase, and China National Knowledge Infrastructure. Data on changes in Schirmer’s test, tear breakup time (TBUT), corneal staining score, and OSDI score were collected for meta-analysis.,Results,A total of 621 affected eyes from 9 independent clinical studies were included. 6 studies conducted Schirmer's test after the application of 3% DQS. Meta-analysis showed that the difference between 3% DQS and control groups was not statistically significant for short-term application (less than or equal to 1 month) (WMD = 0.14,P, = 0.27, 95% CI:-0.11 to 0.39), but was statistically different for long-term application (longer than or equal to 3 months) (WMD = 0.76,P, = 0.03, 95% CI:0.08 to 1.45). For the corneal fluorescence staining score, the data from 6 studies indicated that the improvement was statistically significant for short-term application (WMD = -0.40,P,<,0.00001, 95% CI:-0.72 to -0.08) and but not long-term application (WMD = -0.21,P, = 0.26, 95% CI:-0.57 to 0.15). For TBUT, the data from 9 studies indicated that both short-term and long-term application showed significant improvement (WMD = 1.70,P,<,0.00001, 95% CI:1.38 to 2.03; WMD = 1.52,P,<,0.00001, 95% CI:1.09 to 1.95). Similar results were observed in data from 5 studies with OSDI scores, where both short-term and long-term application showed statistically significant improvements (WMD = -5.41,P,<,0.00001, 95% CI: -7.02 to -3.81; WMD = -6.10,P,<,0.00001, 95% CI:-8.52 to -3.67).,Conclusions,The application of 3% DQS in post-operative cataract patients has a positive effect on improving the ocular surface conditions. Short-term application resulted in lower corneal staining scores, prolonged TBUT, and improved OSDI scores. Long-term application improved Schirmer's test results, TBUT, and subjective symptoms.,Key messages,The updated article suggests that 3% Diquafosol is less effective in the short term after cataract surgery, and that application over three months can improve the patient's ocular surface condition.

Abstract

关键词

Keywords

DiquafosolCataract surgeryOcular surfaceMeta-analysis

references

1 Y.K. Cho, M.S. KimDry eye after cataract surgery and associated intraoperative risk factors Kor J Ophthalmol, 23 (2) (2009), pp. 65-73, 10.3341/kjo.2009.23.2.65

2 X.M. Li, L. Hu, J. Hu, et al.Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery Cornea, 26 (9 Suppl 1) (2007), pp. S16-S20, 10.1097/ICO.0b013e31812f67ca

3 K. Kato, K. Miyake, N. Kondo, et al.Conjunctival goblet cell density following cataract surgery with diclofenac versus diclofenac and rebamipide: a randomized trial Am J Ophthalmol, 181 (2017), pp. 26-36, 10.1016/j.ajo.2017.06.016

4 R. Michael, A. WegenerEstimation of safe exposure time from an ophthalmic operating microscope with regard to ultraviolet radiation and blue-light hazards to the eye J Opt Soc Am Opt Image Sci Vis, 21 (8) (2004), pp. 1388-1392, 10.1364/josaa.21.001388

5 G.M. KeatingDiquafosol ophthalmic solution 3 %: a review of its use in dry eye Drugs, 75 (8) (2015), pp. 911-922, 10.1007/s40265-015-0409-7

6 D. Wu, W.Q. Chen, R. Li, et al.Efficacy and safety of topical diquafosol ophthalmic solution for treatment of dry eye: a systematic review of randomized clinical trials Cornea, 34 (6) (2015), pp. 644-650, 10.1097/ico.0000000000000429

7 S. KohClinical utility of 3% diquafosol ophthalmic solution in the treatment of dry eyes Clin Ophthalmol, 9 (2015), pp. 865-872, 10.2147/opth.S69486

8 X. Zhao, S. Xia, Y. ChenComparison of the efficacy between topical diquafosol and artificial tears in the treatment of dry eye following cataract surgery: a meta-analysis of randomized controlled trials Medicine (Baltim), 96 (39) (2017), Article e8174, 10.1097/MD.0000000000008174

9 D.H. Park, J.K. Chung, D.R. Seo, et al.Clinical effects and safety of 3% diquafosol ophthalmic solution for patients with dry eye after cataract surgery: a randomized controlled trial Am J Ophthalmol, 163 (2016), pp. 122-131 e2, 10.1016/j.ajo.2015.12.002

10 H. Lee, S.M. Kim, S. Choi, et al.Effect of diquafosol three per cent ophthalmic solution on tear film and corneal aberrations after cataract surgery Clin Exp Optom, 100 (6) (2017), pp. 590-594, 10.1111/cxo.12521

11 L. Cui, Y. Li, H.S. Lee, et al.Effect of diquafosol tetrasodium 3% on the conjunctival surface and clinical findings after cataract surgery in patients with dry eye Int Ophthalmol, 38 (5) (2018), pp. 2021-2030, 10.1007/s10792-017-0693-1

12 J. Baek, S.H. Doh, S.K. ChungThe effect of topical diquafosol tetrasodium 3% on dry eye after cataract surgery Curr Eye Res, 41 (10) (2016), pp. 1281-1285, 10.3109/02713683.2015.1122813

13 K. Miyake, N. YokoiInfluence on ocular surface after cataract surgery and effect of topical diquafosol on postoperative dry eye: a multicenter prospective randomized study Clin Ophthalmol, 11 (2017), pp. 529-540, 10.2147/opth.S129178

14 S. Kim, J. Shin, J.E. LeeA randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery Sci Rep, 11 (1) (2021), p. 9124, 10.1038/s41598-021-88589-7

15 Y. Inoue, S. OchiEffects of 3% diquafosol sodium ophthalmic solution on higher-order aberrations in patients diagnosed with dry eye after cataract surgery Clin Ophthalmol, 11 (2017), pp. 87-93, 10.2147/opth.S122542

16 I. Jun, S. Choi, G.Y. Lee, et al.Effects of preservative-free 3% diquafosol in patients with pre-existing dry eye disease after cataract surgery: a randomized clinical trial Sci Rep, 9 (1) (2019), p. 12659, 10.1038/s41598-019-49159-0

17 L. Yang, Y. Jianguo, Q. Shixin, et al.Study on the effect of diquafosol sodium ophthalmic solution combined with sodium hyaluronate eye drops in the treatment of xerophthalmia after cataract surgery J China Prescr Drugs, 7 (18) (2020), pp. 103-104, 10.3969/j.issn.1671-945X.2020.07.055

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of intravenous sedation on patients’ visual experience and vital signs during cataract surgery under topical anesthesia: A randomized controlled trial

Differences in the involved sites among different types of demyelinating optic neuritis in traditional MRI examination: A systematic review and meta-analysis

Patient reported outcomes after implementation of an enhanced depth of focus intraocular lens with low postoperative myopia

Research progress of lens zonules

Efficacy and safety of monoclonal antibodies in neuromyelitis optica spectrum disorders: A survival meta-analysis of randomized controlled trials

Related Author

No data

Related Institution

International Eye Cataract Retina Center, Mount Elizabeth Medical Center and Farrer Park Medical Center

Future Vision Eye Care and Research Center, Mumbai

Aravind Eye Hospital

Department of Ophthalmology, The Chinese People's Liberation Army General Hospital

Department of Ophthalmology of Specialist Hospital in Chojnice, Lesna, Chojnice

⁰