最新刊期
期 2 ， 2021
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Purpose
To investigate the application of critical flicker fusion frequency (CFF) in demyelinating optic neuritis (DON).Methods
A cross-sectional study. A total of 127 eyes in 69 DON patients and 63 eyes in 33 healthy control (HC) groups were included between January 2021 to September 2021 from Department of Ophthalmology, PLA General Hospital. Patients underwent best-corrected visual acuity (BCVA), visual field, optical coherence tomography (OCT), flash visual evoked potential (F-VEP), and CFF examinations. The affected eyes were divided into aquaporins 4 (AQP4-), myelin oligodendrocyte glycoprotein (MOG-), and double negative DON according to serum antibody; mild, moderate, severe degree visual impairment according to BCVA ≥ 0.5, 0.1-0.5, < 0.1; and 4 groups: < 1, 1 ∼< 3, 3 ∼ < 6 and > 6 months according to time interval from onset to CFF examination. One-way ANOVA was used to perform above subgroup analysis. The correlations between CFF and F-VEP peak time, peak value, BCVA and mean visual filed defect (MD) were analyzed in order via Pearson correlation analysis.Results
he trichromatic values of red, green, and yellow in DON affected eyes were 21.83 ± 9.03, 23.66 ± 10.21, 24.09 ± 10.77 Hz, respectively, which was significantly reduced compared with the HC group (t = -14.82, -14.22, -14.00; P < 0.001). The subgroup analysis showed no significant difference between different antibody subtypes (P = 0.914 <0.848 <0.604), whereas, a significant decrease of CFF trichromatic value was found in severe visual acuity impairment group (P < 0.001). There was a significant difference in CFF- trichromatic values at different time points (P < 0.001), to be specific, CFF fluctuated under 20Hz within 3 months after onset and tended to be stable around 24-28Hz. Correlation analysis showed that the peak time of F-VEP (r = -0.486, -0.515, -0.526; P < 0.001), BVCA (r = -0.640, -0.659, -0.642; P < 0.001), were negatively correlated with CFF trichromatic values, MD and CFF were positively correlated (r = 0.486, 0.453, 0.476; P = 0.003, 0.006, 0.004).Conclusions
A significant decrease of CFF value was found in DON-affected eyes, and it has a good correlation with BCVA, MD and latency of F-VEP, and can better reflect the impairment of visual function关键词：Critical flicker fusion frequency;Demyelinating optic neuritis- 6
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发布时间：2023-11-15 - 摘要：
Purpose
To evaluate the relationship between axial length (AL) and spherical equivalent refraction (SER) in Chinese children.Methods
This hospital-based cross-sectional study included 1208 eyes (from 617 Chinese boys and 591 Chinese girls), ranging between 2 and 12 years. All subjects were divided into subgroups according to the spherical equivalent refraction (SER) (hyperopia, emmetropia, and myopia) and age (2–6 years, 7–9 years, and 10–12 years). Comparisons were made between age, sex, and SER groups. Multiple linear regression analysis was used to evaluate the correlation of AL and SER for all groups.Results
The mean AL and SER were significantly different among the three age groups: 2–6 years group (AL: 22.24 ± 1.59 mm; SER: 0.73 ± 2.67 D); 7–9 years group (AL: 23.49 ± 1.10 mm; SE: -0.68 ± 1.97 D) and 10–12 years group (AL: 24.33 ± 1.02 mm; SER: -1.72 ± 1.86 D). Boys showed longer AL compared with the girls (23.66 ± 1.51 mm vs 23.05 ± 1.32 mm). However, as for SER, the girls (−0.70 ± 2.17 D) showed smaller SER (more myopia) compared with the boys (−0.4 ± 2.48 D). After adjusting for age and sex, the SER tended to decrease (became more myopic) 1.23 D (95% CI: 1.15–1.30D) with a 1 mm increase of AL. Among the different SER groups, the SER tended to become more myopic per mm of AL by 1.09 D (95% CI: 0.97–1.21D) for the myopia group, 1.38 D (95% CI: 1.23–1.54 D) for the hyperopia group, and 0.05 D (95% CI: 0.02–0.08 D) for the emmetropic group. In addition, an increase of 1 mm elongation of AL showed a decrease of SER by 1.05 D (95% CI: 0.90–1.20 D) among 2 – 6-year-olds, by 1.40 D (95% CI: 1.30–1.51 D) among 7 – 9-year-olds, and by 1.37 D (95% CI: 1.21–1.52 D) among 10–12-year-olds. As for sexual differences, the girls 1.68 D, (95% CI: 1.57–1.79 D) showed a more significant myopic shift of SER with a 1 mm increase of AL compared with the boys (0.94 D, 95% CI: 0.84–1.04 D).Conclusions
Our results indicated a strong linear relationship between SER and AL and an early-rising trend of myopia in Chinese children.关键词：Myopia;Axial length;Spherical refraction;Refractive error;Children;Age- 6
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发布时间：2023-11-15 - 摘要：
Purpose
To determine organisms present in the conjunctiva of children before and after orthokeratology lens wear, using MALDI-TOF mass spectrometry.Methods
Conjunctival samples were collected from children aged 8–12 years (inclusive) at baseline and on three occasions over the first six months of orthokeratology treatment. All lenses were disinfected using the povidone iodine-based solution every day after use. Specimens were cultured and all isolated colonies were identified using MALDI-TOF mass spectrometry. Numbers of organisms and diversity were compared over the study period and the presence of any ocular pathogens noted and participants informed, where appropriate, to enhance their compliance with lens care routine.Results
Organisms isolated from 76 children were generally similar to other studies employing culture methods. However, MALDI-TOF results yielded a wider range of species of micrococci and corynebacteria, as well as a few less frequently reported organisms. Only one culture yielded fungi. Ocular pathogens were only isolated from 9 subjects (4 before lens wear and 5 after lens wear), each on one occasion only. Diversity and numbers of organisms fell slowly over the period of the study, but the changes were not significant.Conclusions
Lens wear did not affect the overall content of the ocular microbiome, but the diversity was somewhat reduced. The incidence of ocular pathogens was low, suggesting that risk of ocular infection was not substantially increased by orthokeratology treatment using a povidone-iodine disinfecting solution.关键词：Ocular microbiome;Myopia control;MALDI-TOF;Orthokeratology;Children- 5
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发布时间：2023-11-15 - 摘要：
Background
Magnetic resonance imaging (MRI) plays a significant role in assessing optic neuropathy and providing more detailed information about the lesion of the visual pathway to help differentiate optic neuritis from other visual disorders. This study aims to systematically review the literature and verify if there is a real difference in lesion location among different demyelinating optic neuritis (DON) subtypes.Methods
A systematic search was conducted including 8 electronic databases and related resources from the establishment of the database to August 25th, 2020. We classified DON into 5 subtypes and divided the visual pathways into five segments mainly comparing the differences in the involved visual pathway sites of different subtypes.Results
Fifty-five studies were included in the analysis, and the abnormal rate was as high as 92% during the acute phase (within 4 weeks of symptom onset). With respect to lesion location, the orbital segment of the optic nerve was the most frequently involved (87%), whereas optic tract involvement was very rare. Involvement of the orbital segment was more common in myelin oligodendrocyte glycoprotein antibody-related optic neuritis (MOG-ON) (78%) and chronic relapsing inflammatory optic neuropathy (CRION) (81%), while the lesion was found to be located more posteriorly in neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON). With respect to lesion length, approximately 77% of MOG-ON patients had lesions involving more than half of the optic nerve length.Conclusions
MRI examination is recommended for DON patients in the acute phase. In MOG-ON, anterior involvement is more common and the involved length is mostly more than 1/2 of the optic nerve length, whereas posterior involvement, intracranial segment, optic chiasm, or optic tract, is more common in NMOSD-ON.Prospero registration number
CRD42020222430 (25-11-2020);关键词：Demyelinating optic neuritis;Magnetic resonance imaging;A systemic review;Meta-analysis- 6
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发布时间：2023-11-15 -
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