Recent progress of nanomedicine in managing dry eye disease

Zeen Lv; Su Li; Guixiang Zeng; Ke Yao; Haijie Han

doi:10.1016/j.aopr.2024.01.008

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Recent progress of nanomedicine in managing dry eye disease

Review | 更新时间：2024-05-29

- Recent progress of nanomedicine in managing dry eye disease
- AOPR Vol. 4, Issue 1, Pages: 23-31(2024)
- 作者机构：
  
  1. Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases,Hangzhou,China,310009
  2. Department of Pediatrics, No. 903 Hospital of PLA Joint Logistic Support Force,Hangzhou,China,310013
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2024.01.008
  CLC：
- Published：2024，
扫描看全文
Zeen Lv, Su Li, Guixiang Zeng, et al. Recent progress of nanomedicine in managing dry eye disease. [J]. AOPR 4(1):23-31(2024)
DOI：

Zeen Lv, Su Li, Guixiang Zeng, et al. Recent progress of nanomedicine in managing dry eye disease. [J]. AOPR 4(1):23-31(2024) DOI： 10.1016/j.aopr.2024.01.008.

摘要

Abstract

BackgroundDry eye disease (DED) is a commonly reported ocular complaint that has garnered significant attention in recent research. The global occurrence of DED ranges from 5% to 50%

impacting a substantial proportion of individuals worldwide with increasing frequency. Although topical administration remains the mainstream drug delivery method for ocular diseases

it suffers from drawbacks such as low bioavailability

rapid drug metabolism

and frequent administration requirements. Fortunately

the advancements in nanomedicine offer effective solutions to address the aforementioned issues and provide significant assistance in the treatment of DED.Main textDED is considered a multifactorial disease of the ocular surface and tear film

in which the integrity of tear film function and structure plays a crucial role in maintaining the homeostasis of the ocular surface. The conventional treatment for DED involves the utilization of artificial tear products

cyclosporin

corticosteroids

mucin secretagogues

and nonsteroidal anti-inflammatory drugs. Furthermore

nanomedicine is presently a significant field of study

with numerous clinical trials underway for various nanotherapeutics including nanoemulsions

nanosuspensions

liposomes

and micelles. Notably

some of these innovative nanoformulations have already received FDA approval as novel remedies for DED

and the advancement of nanomedicine is poised to offer enhanced prospects to solve the shortcomings of existing treatments for DED partially.ConclusionsThis article provides an overview of the latest advancements in nanomedicine for DED treatment

while the field of DED treatment is expected to witness a remarkable breakthrough shortly with the development of nanomedicine

bringing promising prospects for patients worldwide suffering conditions.

关键词

Keywords

Dry eye diseaseNanoparticlesDrug deliveryNanomedicineOcular surface

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The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery: A meta-analysis for time of intervention

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